Effects of the antioxidant activity of vitamin D on skin aging and the immune response

Skin aging is a multifactorial process associated with intrinsic and extrinsic factors that promote oxidative stress, inflammation, and the progressive deterioration of skin structure and function. In this context, vitamin D has gained relevance because of its involvement in skin homeostasis and its antioxidant, anti-inflammatory, and immunomodulatory properties (Bocheva et al., 2021). The objective of this research was to analyze the scientific evidence on the antioxidant effects of vitamin D, its influence on the immune response, and its possible contribution to the prevention of skin aging. Documentary research with a qualitative approach was conducted through a systematic review and analysis of recent scientific literature. The findings indicate that vitamin D and its metabolites participate in the regulation of oxidative stress through mechanisms related to the Nrf2 pathway, in addition to modulating inflammatory processes, immune responses, and cellular protection mechanisms (Bocheva et al., 2021; Miao & Goltzman, 2023). Likewise, the evidence suggests possible involvement in maintaining homeostasis and the integrity of the skin barrier. It is concluded that vitamin D has potential as a modulator of mechanisms associated with skin aging; however, the available evidence in humans is still limited, so clinical studies are required to establish its preventive and therapeutic efficacy.