Self-Reported vs Objective Cerebrovascular Burden: Association with Depression and Cognitive Performance

Abstract

Introduction: Cerebrovascular burden (CVB) contributes to neurocognitive and behavioral decline in aging. While MRI is the gold standard for assessing CVB, its availability in large community samples is limited. Previous studies have used biomarkers (e.g., A1C) or self-reported comorbidities (e.g., diabetes) to assess CVB.