InterventionsHuman trial145 participants24 monthsRandomised trial

A 2-year Trial of Metformin to Reduce Frailty in Older Adults with Glucose Intolerance

GSA 2025 Abstract

Abstract

It has been postulated that metformin may extend healthspan but no long-term trials have been done in humans. We conducted a randomized, double-blinded, placebo-controlled clinical trial of metformin to reduce frailty in older adults (≥65 years) with glucose intolerance.

The paper

Espinoza S, Wang CP, Musi N

GSA 2025 Abstract · 31 Dec 2025 · CC BY

Presented at GSA 2025

doi.org/10.1093/geroni/igaf122.1648