Caloric Restriction and Changes in Geroscience Blood-Based Biomarkers in Older Adults
GSA 2025 Abstract
Abstract
Intermediate endpoints are needed to evaluate the effect of interventions targeting the biology of aging in clinical trials. We examined associations between randomization to caloric restriction (CR), as well as achieved weight loss, and a consensus derived panel of blood-based geroscience biomarkers in 768 older adults (mean age, 67.4±5.
