INVESTIGATING MEDIATORS OF SYSTEMIC MITOCHONDRIAL BIOENERGETICS IN COGNITIVE IMPAIRMENT AND ALZHEIMER’S DISEASE

Abstract

We previously showed peripheral blood mononuclear cell (PBMC) and platelet mitochondrial bioenergetic capacities are lower in older adults with Alzheimer’s disease (AD), with notable changes in fatty acid oxidation (FAO)-mediated respiration. The metabolic pathways underlying mitochondrial functional differences remain un-identified.

The paper