FREE TESTOSTERONE, SEX HORMONE BINDING GLOBULIN, AND INCIDENT FRAILTY IN MEN WITH HIV

Abstract

Background: Older men with HIV (MWH) have a higher prevalence of frailty than matched men without HIV, but the underlying mechanisms are unclear. Testosterone (T) contributes to higher muscle (mass, strength), and it binds to sex hormone-binding globulin (SHBG), which regulates testosterone bioavailability to the tissues.