MID-LIFE AND LATE-LIFE ENVIRONMENTAL EXPOSURES ON DEMENTIA RISK: THE MODIFYING EFFECTS OF APOE

Abstract

Increasing evidence supports a deleterious effect of late-life air pollution exposure on dementia risk that is exacerbated among older ApolipoproteinE-4 (ApoE-4) carriers. However, the protracted effects of mid-life occupational exposures on dementia outcomes, and potential interactions with ApoE, are unknown.