Older estimated heart age linked to heart failure risk
Compared with the normal group, heart failure hazard ratios—measures of relative risk over time—were 2.04, 2.11, 2.96 and 1.54 across four cohorts.
837,666 participants, multicenter
Limit: The abstract did not report follow-up duration or absolute risks
Edited by Boris Djordjevic · AgingResearch.News
An observational study examined four groups of 112,761, 37,734, 41,552 and 93,090 people without previous heart failure in South Korea, the United Kingdom and the United States. Researchers applied an artificial intelligence model to electrocardiograms, recordings of the heart’s electrical activity, to estimate biological age. They classified an estimate as older when it exceeded a person’s actual age by more than seven years.
People in this older-age group had a higher risk of developing heart failure than those in the normal group in every cohort. The reported risk measures accounted for other factors. In one South Korean cohort, the association was similar across all three heart failure subtypes studied.
Why it matters
The researchers suggested that this noninvasive measure of biological aging may help assess future heart failure risk, including risk of different subtypes.
Caveats
These observational links do not establish cause and effect, and the findings concern people without previous heart failure. This conference abstract did not report follow-up duration or absolute risks.
- Deep learning
- Heart failure
- Heart failure with mildly reduced ejection fraction
- Heart failure with preserved ejection fraction
- Heart failure with reduced ejection fraction
- Humans
