Early Tau and Amyloid Co‐Pathology Linked to Basal Forebrain Atrophy in Cognitively Unimpaired Older Individuals

Abstract

Background: The cholinergic basal forebrain (BF) system, particularly the nucleus basalis of Meynert (Ch4), is selectively vulnerable to early pathological changes in Alzheimer’s disease (AD). However, the onset and mechanisms of Ch4 atrophy in relation to AD pathologies are not well understood.

The paper