Relationship between tau and SV2A in the neurotypical population and translation to the Down syndrome population

Abstract

Background: Synaptic density loss has been proposed as a major neuronal mechanism through which cognition degrades in Alzheimer’s disease (AD). PET imaging studies have observed synaptic density change across the AD continuum using SV2A radiotracer [ ¹¹ C]UCB‐J.

The paper