Comparing Off‐Target Meningeal and Skull Signal in Head‐to‐Head MK‐6240 and AV‐1451 Tau PET

Abstract

Background: Tau tangle deposition is associated with Alzheimer disease (AD) clinical symptomology and cognitive decline. Such deposition can be measured in vivo using positron emission tomography (PET). Off‐target signal from extra‐cerebral sources, such as skull or meninges, may bias quantification but the impact is currently unknown.

The paper