Amygdala microstructural changes in subjective cognitive decline as measured by MRI diffusion kurtosis, neurite orientation dispersion and density, and magnetization transfer imaging

Abstract

Background: Our prior work applying diffusion kurtosis imaging (DKI) to subjective cognitive decline (SCD) showed significantly decreased kurtosis fractional anisotropy (KFA) and significantly increased mean kurtosis (MK) for SCD in bilateral amygdala, an early site for tau tangle pathology ¹ .