BiomarkersHumans
Reactive Astrogliosis predicts Amyloid Accumulation before the Preclinical Stage of Alzheimer's Disease
AAIC 2025 Abstract
Abstract
Background: Monoamine Oxidase‐B (MAO‐B) is overexpressed in reactive astrocytes, playing a crucial role in neurodegeneration. Recently, increased binding of the PET MAO‐B tracer ¹⁸ F‐SMBT‐1 has been shown in preclinical Alzheimer’s disease (AD) stages.
The paper
Vincent Doré, Pierrick Bourgeat, Ryuichi Harada, Victor L. Villemagne
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Shozo Furumoto, Rachel S. Mulligan, Ying Xia, Ishara Paranawithana, Simon Matthew Laws, Azadeh Feizpour, Svetlana Bozinovski, Kun Huang, Brian J. Lopresti, Miloš D. Ikonomović, Jürgen Fripp, Nobuyuki Okamura, Christopher C. Rowe,Commonwealth Scientific and Industrial Research Organisation · University of Pittsburgh
AAIC 2025 Abstract · 23 Dec 2025 · CC BY
Presented at AAIC 2025
