Trajectories of Cognitive Decline over 24 months in Older Adults with Treatment‐Resistant Late‐life Depression at risk for Dementia

Abstract

Background: Individuals with Late‐life depression (LLD) are at elevated dementia‐risk and those with treatment‐resistant LLD (TRLLD), defined by failing at least two treatment regimens, may be at especially high dementia‐risk. We examined how TRLLD (remission status/severity) predicts cognitive decline over 24‐months.