Medial Temporal Lobe Flexibility as an Early Marker of Alzheimer’s Risk in African Americans with ABCA7‐80 Variant: Application to Multivariate Imputation by Chained Equations using Random Forest

Abstract

Background: Alzheimer’s disease (AD) is characterized by progressive neurodegeneration and cognitive decline. Medial Temporal Lobe (MTL) Flexibility, measured from dynamic functional connectivity in resting‐state fMRI, may serve as a biomarker for Mild Cognitive Impairment (MCI) and AD.