AAIC 2025 Abstract
Coordination of CSF and Peripheral Circulation Proteomics across the AD Spectrum
By Jijing Wang, Stephanie A. Schultz, Erik C. B. Johnson, Show 7 more authorsThe Dominantly Inherited Alzheimer Network (DIAN)
Study in peopleMechanisms
Abstract
Background: Progressive disruption of the blood–brain barrier (BBB) is believed to contribute to Alzheimer’s disease (AD) pathophysiology. BBB deterioration may increase crosstalk between the central nervous system (CNS) and the periphery, potentially resulting in more closely aligned inflammatory states across compartments.
