The Role of Reproductive Aging and Surgeries for Alzheimer's Disease and Related Dementias (ADRD) Diagnoses in the Cardiovascular Health Study

Abstract

Background: Most US individuals with ADRD are women. Menopause typically occurs in midlife, accompanied by declines in potentially neuroprotective and cardioprotective hormones. Earlier menopause leads to earlier exposure to decreased sex hormones, potentially increasing ADRD risk.