Sex‐Specific Differences in Cognition of Mthfr Deficient Mice

Abstract

Background: Methylenetetrahydrofolate reductase (Mthfr) catalyzes the major circulating form of folate. Common Mthfr polymorphisms increase the risk of various neurological disorders. Moreover, heterozygous knockout (Mthfr +/‐) mice show diminished blood‐brain‐barrier integrity, reduced pericytes, and reduced vascular density.