AAIC 2025 Abstract

Neuropsychiatric symptoms are associated with tau pathology in Autosomal Dominant Early Onset Alzheimer's Disease caused by PSEN1 and APP mutations

Study in peopleMechanisms

Abstract

Background: This study aimed to characterize the relationship between neuropsychiatric symptoms and tau pathology in vivo within a cohort of participants of predominantly Mexican ancestry at risk for fully penetrant Autosomal Dominant Early Onset Alzheimer's disease (ADAD) caused by mutations in PSEN1 and APP genes.

The paper

University of California San Diego; University of Southern California

AAIC 2025 Abstract, 25 Dec 2025, CC BY

Presented at AAIC 2025

doi.org/10.1002/alz70857_105799