Diagnostic blind spot in clinical manifestations: anosognosia trajectory in preclinical Alzheimer's is linked to core pathophysiology, astrocytic reactivity, and structural changes in cognitive control and self‐referential brain regions

Abstract

Background: Anosognosia, lack of awareness of clinical impairment, is a common manifestation in Alzheimer's disease (AD). This phenomenon is linked to AD neuropathology and dementia progression, but this is not acknowledged in Mild Cognitive Impairment (MCI) diagnostic criteria.