In vivo mean diffusivity is associated with neuropathology markers of Alzheimer's disease

Abstract

Background: Diffusion weighted imaging (DWI) of gray matter can identify microstructural changes that have recently been shown to correlate with biomarkers of Alzheimer's disease (AD). Hence DWI‐based metrics such as mean diffusivity (MD) hold great promise to serve as an early and sensitive biomarker of AD pathology (Spotorno et al.

The paper