AAIC 2025 Abstract

Tau deposition can commence in multiple cortical regions in Alzheimer's trajectory before coalescing into Braak Stages

Study in peopleMechanisms

Abstract

Background: Tau pathology is a key hallmark of Alzheimer's Disease (AD), with its spread and regional deposition strongly correlated to cognitive decline. Braak staging describes a characteristic progression, beginning in the medial temporal lobe and extending to isocortical regions ¹ .

The paper