BiomarkersHumans
Mosaic Loss of Chromosome Y and Plasma Aβ42/p‐tau181 Ratio as Biomarkers for Alzheimer's Disease in the Midwestern Amish
AAIC 2025 Abstract
Abstract
Background: In aging men, mosaic loss of chromosome Y (mLOY) is a possible biomarker for increased risk of disease, including Alzheimer disease (AD). We previously reported mLOY increased with age and carriers of mLOY had an increased risk of AD.
The paper
Yeunjoo E. Song, Ping Wang, Reneé A. Laux, Jonathan L. Haines
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Sarada L. Fuzzell, Sherri D. Hochstetler, Kristy L. S. Miskimen, Audrey H. Lynn, Weihuan Wang, Yining Liu, Noel C. Moore, Alex V. Gulyayev, Daniel A. Dorfsman, Laura J. Caywood, Jason E. Clouse, Sharlene D. Herington, Michael B. Prough, Susan H. Slifer, Larry Deon Adams, Patrice G. Whitehead, Jeffery M. Vance, Michael L. Cuccaro, Paula K. Ogrocki, Alan J. Lerner, Margaret Pericak‐Vance, William K. Scott, William S. Bush,Case Western Reserve University
AAIC 2025 Abstract · 8 Jan 2026 · CC BY
Presented at AAIC 2025
