Association of blood‐based DNA methylation measures of biological aging with cognitive decline and hippocampal atrophy
AAIC 2025 Abstract
Abstract
Background: Processes related to biological aging may underpin dementia pathophysiology. Deoxyribonucleic acid methylation (DNAm) clocks have been positioned as estimators of biological age. However, the predictive ability of blood‐based DNAm biomarkers of aging for cognitive decline and brain atrophy, remains under‐investigated.
- DNA methylation
- Epigenetic regulation of gene expression
- Dementia
- Mild cognitive impairment
- Cerebrovascular disease
- Humans
