ApoE4 accelerates p ‐tau driven tau aggregation and spread in Alzheimer's Disease in a allele‐dose dependent manner

Abstract

Background: Understanding factors influencing Alzheimer's disease (AD) progression is crucial for optimising treatment timing and targets. A major genetic risk factor, the Apolipoprotein E ε4 allele (ApoE4), is associated with earlier tau pathology accumulation and spread at lower amyloid‐beta (Aβ) levels (Steward, JAMA Neurol, 2023).

The paper