Vascular pathology drives the association of plasma GFAP with gray matter atrophy and cognitive decline in amyloid‐negative individuals

Abstract

Background: Amyloid (Aβ) pathology potentiates the association between GFAP, a biomarker for reactive astrogliosis, and neurodegeneration, while it remains unclear whether GFAP is associated with neurodegeneration without Aβ abnormalities.