MechanismsHumans
APOE ε4 Modulates Beta‐Amyloid Clearance via Cerebrospinal Fluid Dynamics: Insights from Nonhuman Primate and Clinical Studies
AAIC 2025 Abstract
Abstract
Background: Efficient cerebrospinal fluid (CSF) circulation plays a critical role in clearing metabolic waste, including beta‐amyloid (Aβ), a key biomarker of AD. Impaired CSF dynamics may contribute to amyloid accumulation and disease progression.
The paper
Jeongchul Kim, Megan E. Lipford, Richard A. Barcus, Christopher T. Whitlow
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Hongyu Yuan, Qing Lyu, Jeremy Patton Hudson, Sam N. Lockhart, Timothy M. Hughes, Courtney L. Sutphen, Brett M. Frye, Kiran Kumar Solingapuram Sai, Marc D. Rudolph, Carol A. Shively, Thomas C. Register, Michelle M. Mielke, Suzanne Craft,Wake Forest University Health Sciences
AAIC 2025 Abstract · 8 Jan 2026 · CC BY
Presented at AAIC 2025
