Voxel‐wise deconvolution and surface shape analysis for the correction of meningeal off‐target bindings in tau PET

Abstract

Background: Increasingly popular second‐generation tau PET tracers such as PI‐2620 and MK‐6240 often exhibits off‐target bindings in the meningeal areas. These artifacts lead to abnormally high uptake values on the cortex and complicate the interpretation of tau‐PET scans.

The paper