Cerebrospinal fluid synaptic markers are associated with global white matter microstructure in cognitively unimpaired participants

Abstract

Background: Higher levels of the synaptic proteins neuropentraxin 2 (NPTX2) and neurosecretory protein VGF in cerebrospinal fluid (CSF) are associated with reduced cognitive decline among older adults, but the mechanisms underlying their beneficial effects on cognition are poorly understood.