MTHFR 1298C and 677T Interactions with APOE e4 and White Matter Hyperintensity Volume on Amyloid‐Positive Status in Cognitively Unimpaired Older Adults

Abstract

Background: The 677T and 1298C alleles of MTHFR (methylenetetrahydrofolate reductase) are both involved in homocysteine processing and are associated with increased risks for both Alzheimer's disease (AD) and cardiovascular disease.