Focus on orexinergic neurons: omics study reveals glial changes and neuroinflammation in the lateral hypothalamic area as key factors driving the initial vulnerability in Alzheimer's disease

Abstract

Background: The neuromodulatory subcortical system (NSS) is vital for homeostatic balance and is among the earliest regions to accumulate tau pathology in Alzheimer's disease (AD), undergoing marked degeneration by late‐stage AD. Within the NSS, orexinergic neurons (Orx N ) regulate wakefulness, appetite, and sleep‐wake transitions.

The paper