Evaluating the Presence of a Physiologic Ceiling in Amyloid Trajectories: Insights from the Sampled Iterative Local Approximation (SILA) Algorithm and Simulations

Abstract

Background: With continued collection of amyloid positron emission tomography (PET) neuroimaging and new quantitative approaches to analyze longitudinal PET data, the Alzheimer's disease (AD) research field is now positioned to determine amyloid trajectories empirically.

The paper