AAIC 2025 Abstract
APOE4 drives neuroinflammation and lipid dysbiosis in Alzheimer's disease by modulating lipid compositions and cell adhesion molecules in brain‐derived extracellular vesicles
Experiments in animalsMechanisms
Abstract
Background: Extracellular vesicles (EVs) are key mediators in transferring pathological proteins associated with Alzheimer's disease (AD). The apolipoprotein E (APOE) gene, particularly the ε4 allele, is a major genetic risk factor for late‐onset AD.
