Mthfr deficiency and SARS‐CoV‐2 infection synergistically deplete dopamine and upregulate α‐synuclein increasing the risk of Parkinson's disease

Abstract

Background: Methylene tetrahydrofolate reductase (MTHFR) is a critical enzyme in one‐carbon metabolism that affects several biological processes such as nucleotide synthesis, amino acid homeostasis, DNA methylation, redox defense, and neurotransmitter synthesis including dopamine.