InterventionsAnimals
Exploring the therapeutic potential of metformin on cognitive function, amyloid pathology, and microglial homeostasis in Alzheimer's disease models
AAIC 2025 Abstract
Abstract
Background: Alzheimer's Disease (AD) and type 2 diabetes mellitus (T2D) share an exacerbated neuroinflammatory response coordinated by microglial cells and a decreased autophagic flux. Treatment with the normoglycemic metformin (MET) has been associated with reduced microglial activation and restored autophagy in T2D models.
The paper
Nicolás Gabriel González Pérez, Carlos Javier Pomilio, Luciano Arcucci, Flavia Saravia
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Natalí B. Rasetto, Melisa Bentivegna, Melina Bellotto, Jessica Presa, Soledad Porte Alcon, Juan Beauquis,Consejo Nacional de Investigaciones Científicas y Técnicas
AAIC 2025 Abstract · 23 Dec 2025 · CC BY
Presented at AAIC 2025
