Female‐Specific Molecular Dysregulation in Alzheimer's Disease: miRNA and Gene Dynamics in 3xTg‐AD Mice

Abstract

Background: Women are disproportionately affected by Alzheimer's disease (AD), accounting for approximately two‐thirds of cases. This disparity arises from multifactorial factors, including greater longevity, hormonal changes, genetic and biological differences, cognitive reserve, lifestyle, and sex‐specific pathophysiology.

The paper