Pleiotropic effects of Apolipoprotein (ApoE) 4 on executive function in mice and humans

Abstract

Background: ApoE4 is the strongest genetic risk factor for late‐onset Alzheimer's disease (AD). Compared to ApoE4 noncarriers (ApoE4‐), ApoE4 carriers (ApoE4+) exhibit earlier onset and more rapid progression of memory impairment.

The paper