Phenomics Study Reveals Predictable Converging Molecular Signatures in CTE, Alzheimer's and Models of Mild TBI

Abstract

Background: Traumatic brain injury (TBI) accelerates risk for multiple Alzheimer's Disease and Related Dementias (ADRDs) featuring Tau protein hyperphosphorylation and tauopathy. Mild TBI (mTBI) causes a temporary disruption of brain function typically caused by blast, blow, or jolt to the head.

The paper