AAIC 2025 Abstract
APOE Alleles Modify Symptom Onset in Early‐Onset Alzheimer's Caused by the PSEN1 A431E Mutation
By César A. Valdez-Gaxiola, Frida Rosales Leycegui, Martha Gallegos Arreola, Sofía Dumois-Petersen, Figuera Luis E.
Study in peoplePopulations
Abstract
Background: Alzheimer's disease (AD) is the most common neurodegenerative disorder, characterized by neuropathological hallmarks such as amyloid β‐protein plaques, leading to neuronal loss. Early‐Onset Alzheimer's Disease (EOAD), which manifests before the age of 65, is a rare condition often associated with specific genetic variants.
