AAIC 2025 Abstract
Synergy between UCH‐L1 and synaptic loss in Alzheimer's disease retina, predicting cognitive impairment
By Altan Rentsendorj, Dieu-Trang S. Fuchs, Jean-Philippe Vit, Show 11 more authorsMaya Koronyo-Hamaoui
Study in peopleBiomarkers
Abstract
Background: Alzheimer's disease (AD) pathology extends beyond the brain to the neurosensory retina. Ubiquitin carboxyl‐terminal hydrolase L1 (UCH‐L1), a key enzyme in the ubiquitin‐proteasome system, has a synaptic protective function and was recently implicated in amyloid β‐protein (Aβ) plaque accumulation in AD brains.
