Acheta domesticus

1. Rapamycin improves maximum running time in A. domesticus (d = -2.30 to -1.32, P < 0.0001).

   “Rapamycin and phenylbutyrate extended maximum running time (d = -2.30 to -1.32, P < 0.0001)”

   Model organismstreadmill performance after 2-week intermittent dosing2-week

   The house cricket (Acheta domesticus) as a scalable invertebrate model for gerotherapeutic testing · GSA 2025 abstract · 31 Dec 2025

2. Rapamycin improves olfactory preference in A. domesticus (d = -1.82 to -1.28, P’s < 0.01).

   “Olfactory preference was preserved by all drugs (d = -1.82 to -1.28, P’s < 0.01), with strongest effects in rapamycin-treated individuals.”

   Model organismsat 10-weeks geriatric stage after 2-week intermittent dosing2-week

   The house cricket (Acheta domesticus) as a scalable invertebrate model for gerotherapeutic testing · GSA 2025 abstract · 31 Dec 2025

3. Rapamycin extends lifespan in A. domesticus (HR = 0.42, P = 0.0004).

   “Post-treatment lifespan was prolonged by rapamycin (HR = 0.42, P = 0.0004)”

   Model organismspost-treatment survival after 2-week intermittent dosing2-week

   The house cricket (Acheta domesticus) as a scalable invertebrate model for gerotherapeutic testing · GSA 2025 abstract · 31 Dec 2025

Rapamycin →

1. Phenylbutyrate improves maximum running time in A. domesticus (d = -2.30 to -1.32, P < 0.0001).

   “Rapamycin and phenylbutyrate extended maximum running time (d = -2.30 to -1.32, P < 0.0001)”

   Model organismstreadmill performance after 2-week intermittent dosing2-week

   The house cricket (Acheta domesticus) as a scalable invertebrate model for gerotherapeutic testing · GSA 2025 abstract · 31 Dec 2025

Phenylbutyrate →

1. Acarbose shortens lifespan in A. domesticus (HR = 2.92 to 3.03, P's < 0.05).

   “and reduced by acarbose in females (HR = 2.92 to 3.03, P’s < 0.05).”

   Model organismspost-treatment survival after 2-week intermittent dosing2-weekfemales

   The house cricket (Acheta domesticus) as a scalable invertebrate model for gerotherapeutic testing · GSA 2025 abstract · 31 Dec 2025

Acarbose →

1. Linum usitatissimum extends lifespan in A. domesticus.

   “Results demonstrated a significant extension in survival for crickets fed the flax oil diet”

   Model organismscold pressed flax oil added to moistened guinea pig chow mash as a 10% mixture10% mixture11 weeks

   THE INSECT ACHETA DOMESTICUS IS A PROMISING MODEL FOR AGING AND AGING INTERVENTION STUDIES · GSA 2024 abstract · 31 Dec 2024

Linum usitatissimum →