Young mesenchymal stem cell conditioned media

1. Young mesenchymal stem cell conditioned media increases ADORA1 in mouse cells.

   “young mice MSCs CM increased the responsiveness of aged mice PMNs to adenosine activation by upregulating the A1 adenosine receptor expression.”

   Cellsin young MSCs-CM-treated aged PMNs

   Extracellular adenosine released by mesenchymal stromal cells from young hosts boosts the antimicrobial activity of neutrophils from aged hosts against Streptococcus pneumoniae

   Immunotherapy advances·14 May 2026

More on ADORA1

1. Young mesenchymal stem cell conditioned media improves bacterial killing in mouse cells.

   “treatment of PMNs from aged mice with young MSCs-CM significantly increased S. pneumoniae uptake, production of mitochondrial reactive oxygen species, and boosted overall bacterial killing.”

   Cellsex vivo treatment

   Extracellular adenosine released by mesenchymal stromal cells from young hosts boosts the antimicrobial activity of neutrophils from aged hosts against Streptococcus pneumoniae

   Immunotherapy advances·14 May 2026