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Vaginal dilator

Intervention

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 3 countries
  • Humans1

Outcomes

2

Sexual function

upin humans1

1 study

  1. Vaginal dilator improves sexual function in humans.

    “one patient (92 years old) reported experiencing orgasm for the first time following the use of dilators as a pelvic physical therapy”

    Humanspelvic physical therapyfemales

    SAT-112 Vulvovaginal Obliteration: Presentation of Eleven Cases

    ENDO 2025 abstract22 Oct 2025

Vaginal patency

upin humans1

1 study

  1. Vaginal dilator improves vaginal patency in humans.

    “While vaginal estradiol alone was insufficient for maintaining the vaginal opening, the introduction of vaginal dilators proved effective.”

    Humansfollowing opening of inter-labial fusionvagina

    SAT-112 Vulvovaginal Obliteration: Presentation of Eleven Cases

    ENDO 2025 abstract22 Oct 2025

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