Upar-targeting car-t cells

Intervention1 paper3 findings

  • Animals1

Outcomes

3

Healthspan

upin Vertebrata1Very low certainty

1 study

  1. Upar-targeting car-t cells improve healthspan in Vertebrata.

    “single administration of a low dose is sufficient to safely achieve long-term therapeutic and preventive effects in healthspan.”

    Animalsphysiological aginglow dosesingle administration

    PROPHYLACTIC AND LONG-LASTING THERAPEUTIC EFFICACY OF SENOLYTIC CAR T CELLS AGAINST AGE-RELATED PHENOTYPES · GSA 2024 abstract · 31 Dec 2024

Metabolic function

upin Vertebrata1Very low certainty

1 study

  1. Upar-targeting car-t cells improve metabolic function in Vertebrata.

    “they result in significant improvements in both tissue regeneration and metabolic function.”

    Animalsphysiological aging

    PROPHYLACTIC AND LONG-LASTING THERAPEUTIC EFFICACY OF SENOLYTIC CAR T CELLS AGAINST AGE-RELATED PHENOTYPES · GSA 2024 abstract · 31 Dec 2024

Tissue regeneration

upin Vertebrata1Very low certainty

1 study

  1. Upar-targeting car-t cells improve tissue regeneration in Vertebrata.

    “they result in significant improvements in both tissue regeneration and metabolic function.”

    Animalsphysiological aging

    PROPHYLACTIC AND LONG-LASTING THERAPEUTIC EFFICACY OF SENOLYTIC CAR T CELLS AGAINST AGE-RELATED PHENOTYPES · GSA 2024 abstract · 31 Dec 2024

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