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Upar-specific car t cells

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: National Cancer Institute and 3 more
  • Animals1

Outcomes

3

Liver fibrosis

downin mice1

1 study

  1. Upar-specific car t cells decrease liver fibrosis in mice.

    “restore tissue homeostasis in mice in which liver fibrosis is induced chemically or by diet”

    Animalsinduced chemically or by dietliver

    Senolytic CAR T cells reverse senescence-associated pathologies

    Nature17 Jun 2020

More on Liver fibrosis

Senescent cells

downin mice1

1 study

  1. Upar-specific car t cells decrease senescent cells in mice.

    “uPAR-specific CAR T cells efficiently ablate senescent cells in vitro and in vivo”

    Animalsin vitro and in vivo

    Senolytic CAR T cells reverse senescence-associated pathologies

    Nature17 Jun 2020

More on Senescent cells

Lifespan

upin mice1

1 study

  1. Upar-specific car t cells extend lifespan in mice.

    “CAR T cells that target uPAR extend the survival of mice with lung adenocarcinoma that are treated with a senescence-inducing combination of drugs”

    Animalsin mice with lung adenocarcinoma treated with a senescence-inducing combination of drugs

    Senolytic CAR T cells reverse senescence-associated pathologies

    Nature17 Jun 2020

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