Transcranial ultrasound
Intervention1 paper3 findings
C · W · M · H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.
Labs are independent when their papers share no last author and no institution.
Against: findings that point the other way from most findings on the same outcome.
No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.
Company ties: findings with an author at a company, or from a paper that declares the maker’s interest.
- Human trial1
Outcomes
3MDS 3.0
no changein humans1
1 study
MDS 3.0
no changein humans1
Transcranial ultrasound has no effect on MDS 3.0 in humans.
“Caregiver-rated outcomes were stable.”
Human trialcaregiver-ratedUS Pro2000 unfocused ultrasound device5 min three times daily
Home-administered unfocused transcranial ultrasound in subjective cognitive decline and dementia: an open-label, uncontrolled feasibility pilot study · Frontiers in Aging Neuroscience · 28 Sep 2026
Inoue battery
no changein humans1
1 study
Inoue battery
no changein humans1
Transcranial ultrasound has no effect on Inoue battery in humans.
“and the objective cognitive battery, near ceiling at baseline, did not change.”
Human trialnear ceiling at baselineUS Pro2000 unfocused ultrasound device5 min three times daily
Home-administered unfocused transcranial ultrasound in subjective cognitive decline and dementia: an open-label, uncontrolled feasibility pilot study · Frontiers in Aging Neuroscience · 28 Sep 2026
CESD-5
downin humans1
1 study
CESD-5
downin humans1
Transcranial ultrasound decreases CESD-5 in humans.
“Among self-administered participants, depression (CESD-5) declined significantly ( p _FDR = 0.016)”
Human trialin self-administered participantsUS Pro2000 unfocused ultrasound device5 min three times daily
Home-administered unfocused transcranial ultrasound in subjective cognitive decline and dementia: an open-label, uncontrolled feasibility pilot study · Frontiers in Aging Neuroscience · 28 Sep 2026