Terminating SV40T expression
1 paper2 findings
- 1 lab in 1 country
- Funders: China Postdoctoral Science Foundation and 5 more
- Cells1
Outcomes
2Senescence-associated secretory phenotype (SASP)
upin human cells1
1 study
Senescence-associated secretory phenotype (SASP)
upin human cells1
Terminating SV40T expression induces senescence-associated secretory phenotype (SASP) in human cells.
“alterations in gene expression and signaling pathways including DNA repair dysfunction, notably senescence-associated secretory phenotype (SASP)-related genes, such as MMP1, SERPINB2 and VEGFA”
Cellsterminating SV40T expressionepidermis
AgingSep 23, 2024
Mitotic ability
downin human cells1
1 study
Mitotic ability
downin human cells1
Terminating SV40T expression decreases mitotic ability in human cells.
“Inducing a senescent phenotype by terminating SV40T expression revealed a significant reduction in mitotic ability”
Cellsterminating SV40T expressionepidermis
AgingSep 23, 2024