T0901317
- 1 lab in 1 country
- Funders: Agencia Estatal de Investigación and 7 more
- Animals1
Outcomes
4Lipid and ceramide metabolism
upin mice1
1 study
Lipid and ceramide metabolism
upin mice1
T0901317 activates lipid and ceramide metabolism in mice.
“driving a significant transcriptional upregulation of cholesterol efflux pathways and suppressing pro-inflammatory signaling cascades.”
Animalsin hSOD1G93A micespinal cord
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics4 Sep 2026
Inflammation
downin mice1
1 study
Inflammation
downin mice1
T0901317 inhibits inflammation in mice.
“Molecular characterization revealed that the early systemic T0 administration successfully engaged canonical LXR targets in the spinal cord, driving a significant transcriptional upregulation of cholesterol efflux pathways and suppressing pro-inflammatory signaling cascades.”
Animalsin hSOD1G93A micespinal cord
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics4 Sep 2026
Motor coordination
upin mice1
1 study
Motor coordination
upin mice1
T0901317 improves motor coordination in mice.
“T0-treated SOD1G93A mice exhibited delayed body weight loss and sustained improvements in neuromuscular strength and motor coordination.”
Animalsin hSOD1G93A mice
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics4 Sep 2026
Lifespan
upin mice1
1 study
Lifespan
upin mice1
T0901317 extends lifespan in mice.
“Critically, this continuous treatment preserved functional motor unit connectivity, delayed overall clinical progression, and significantly extended median lifespan.”
Animalsin hSOD1G93A miceuntil endpoint
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics4 Sep 2026