Sulfobetaine-type zwitterionic polymers
Intervention1 paper3 findings
In a cell study, intracellularly permeable sulfobetaine-type zwitterionic polymers improve post-thaw viability, recovery, fusion and proliferation of mesenchymal stem cell spheroids. They also reduce ice crystallisation in ethylene glycol-based vitrification solutions during cooling and warming.
- Cells1
Outcomes
3Spheroid fusion behavior and proliferation
upin cells1Very low certainty
1 study
Spheroid fusion behavior and proliferation
upin cells1Very low certainty
Sulfobetaine-type zwitterionic polymers improve spheroid fusion behavior and proliferation in cells.
CellsAfter vitrification and thawingIntracellularly permeable polymersmesenchymal stem cell spheroid
Zwitterionic polymer-mediated intercellular cryoprotection for efficient vitrification of spheroids · Journal of materials chemistry. B · 1 Oct 2026
Post-thaw viability and recovery
upin cells1Very low certainty
1 study
Post-thaw viability and recovery
upin cells1Very low certainty
Sulfobetaine-type zwitterionic polymers improve post-thaw viability and recovery in cells.
CellsCompared with vitrification solution alone or containing nonpermeable polymersIntracellularly permeable polymersmesenchymal stem cell spheroid
Zwitterionic polymer-mediated intercellular cryoprotection for efficient vitrification of spheroids · Journal of materials chemistry. B · 1 Oct 2026
Ice crystallization
downin cells1Very low certainty
1 study
Ice crystallization
downin cells1Very low certainty
Sulfobetaine-type zwitterionic polymers decrease ice crystallization in cells.
CellsIn ethylene glycol-based vitrification solutions during cooling and warming
Zwitterionic polymer-mediated intercellular cryoprotection for efficient vitrification of spheroids · Journal of materials chemistry. B · 1 Oct 2026