Structural support

2 papers2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funders: Conselho Nacional de Desenvolvimento Científico e Tecnológico and 1 more

Humans2

Outcomes

Cognitive function

upin humans1

1 study

Structural support improves cognitive function in humans (β = 0.030, 95% CI [0.021, 0.038], p < .001).
“Increased structural support ( β = 0.030, 95% CI [0.021, 0.038], p < .001) and higher levels of life satisfaction ( β = 0.014, 95% CI [0.009, 0.019], p < .001) were associated with better cognitive performance”
Humans
The buffering effect of structural support and life satisfaction on cognition is independent of adverse events at older ages: Findings from the ELSI‐Brazil study
AAIC 2025 abstract23 Dec 2025

Associations

Cognitive function

upin humans1

1 study

Structural support is associated with cognitive function in humans (0.030, 95% CI [0.021, 0.040]).
“greater structural support (0.030, 95% CI [0.021, 0.040]) and life satisfaction (0.014, 95% CI [0.008, 0.019]) were strongly associated with better cognitive function”
Humans
Cognition in later life: The role of structural support and life satisfaction in the Brazilian Longitudinal Study of Aging (ELSI-Brazil)
Neuropsychology12 Jan 2026